Most women who are already pre-menopausal are found to have uterine fibroids which only become problematic when they grow as big as a lemon. Fibroids are benign tumors in females and it is also the most common. They can cause painful menstruation, painful sexual intercourse, and frequent urination. In rare cases, it also interferes with pregnancy. There are treatments, invasive or non-invasive, available to cure women with uterine fibroids. According to a study conducted by National Institutes of Health, Nattokinase has the ability to dissolve fibrin. Fibrin-eliminating supplements like Nattokinase supplements helps reduce or completely eliminate fibroids.

Nattokinase supplements have other benefits such as prevention of heart related diseases and reduction of high blood pressure. Nattokinase works like plasmin, a natural enzyme which can be found in the body, and breaks down fibrin which is essential for blood clotting. Uterine fibroids affect women near menopausal stage because plasmin production greatly decreases as people become older.